Concept
To adopt and exploit a systems biology approach towards the elucidation of a complex biological process relevant to human health. This requires multidisciplinarity, acquisition and analysis of quantitative data sets and development of robust mathematical models. In this project we combine Europe’s expertise in DNA mismatch repair with sophisticated multidisciplinary technology and expertise in quantitative modeling in order to describe this DNA repair process at different levels of complexity, in an attempt to gain a better understanding of the role of this process in cancer development.