Objectives
The multidisciplinary network of experts in structural biology, biochemistry, biophysics, mathematical modeling and cell biology will have the following tasks:
- Gather quantitative and structural data sets describing the principal steps of DNA mismatch repair
- Integrate and analyze structural and functional data obtained from single molecule and bulk studies
- Develop mathematical models for single and/or multiple steps of the MMR pathway
- Perform analyses at different levels of complexity: from recognition of the mismatch through repairosome assembly to in vivo function
- Combine the well-understood MMR E.coli model system with the cancer-protective human system