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Peter Friedhoff


Michele Christovao, Peter Friedhoff, Ines Winkler
Email
Peter.Friedhoff@chemie.bio.uni-giessen.de
Affiliations
Justus-Liebig-Universität (JLU)
Website
www.uni-giessen.de/biochem/homepage.htm
Expertise
The Institute of Biochemistry of the Justus-Liebig-University Giessen is responsible for teaching biochemistry and quantitative analysis and simulation to biology and chemistry students. Basic as well as applied research carried out in the institute concerns mechanisms and biological function of enzyme acting on nucleic acids (DNA restriction, modification, repair, apoptosis, RNA splicing). In particular, research on DNA enzyme mechanisms spans the experimental range from cell biology to biophysical and biochemical methodologies to understand structure-function relationship. The group of Peter Friedhoff has major expertise regarding the enzymology of bacterial mismatch repair and has contributed much both to the present understanding of the protein complexes formations in DNA mismatch repair.
Selected references
  • Kosinski, J., Plotz, G., Guarne, A., Bujnicki, J. M. & Friedhoff, P. (2008). The PMS2 subunit of human MutLa contains a metal ion binding domain of the iron-dependent repressor protein family. J Mol Biol 382, 610-27
  • Plotz G, Welsch C, Giron-Monzon L, Friedhoff P, Albrecht M, Piiper A, Biondi RM, Lengauer T, Zeuzem S, Raedle J. Mutations in the MutS? interaction interface of MLH1 can abolish DNA mismatch repair. Nucleic Acids Res 2006 34:6574-6586
  • Manelyte L, Urbanke C, Giron-Monzon L, Friedhoff P. Structural and functional analysis of the MutS C-terminal tetramerization domain. Nucleic Acids Res 2006 34:5270-5279
  • Kosinski J, Steindorf I, Bujnicki JM, Giron-Monzon L, Friedhoff P. Analysis of the quaternary structure of the MutL C-terminal domain. J Mol Biol 2005 351:895-909
  • Giron-Monzon L, Manelyte L, Ahrends R, Kirsch D, Spengler B, Friedhoff P. Mapping protein-protein interactions between MutL and MutH by cross-linking. J Biol Chem 2004 279:49338-49345