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Claire Wyman


Rini de Crom, Claire Wyman, Joyce Lebbink, Klaas Hermans
Email
c.wyman@erasmusmc.nl
Affiliations
Radiation Oncology and
Cell Biology & Genetics,
Erasmus University Medical Center
Rotterdam
Website
http://web.mac.com/carolwymanmac/
Expertise
The Molecular Radiation Biology Group in the Department of Genetics and Department of Radiation Oncology at the Erasmus University Medical Center studies mechanisms and biological function of complex genome transactions. In particular research on DNA repair mechanisms, spanning the experimental range from animal models to single molecule imaging. The group of Claire Wyman use biochemical and enzymatic approaches in combination with single molecule techniques (scanning force microscopy and fluorescence imaging) to understand the mechanisms of DNA repair at the molecular level.
Selected references
  • van Mameren, J., M. Modesti, R. Kanaar, C. Wyman, E.J.G. Peterman, and G.J.L. Wuite. Counting RAD51 proteins disassembling from nucleoprotein filaments under tension. Nature 2008, PMID: 19060884
  • Modesti, M., D. Ristic, T. van der Heijden, C. Dekker, J. van Mameren, E.J. Peterman, G.J. Wuite, R. Kanaar and C. Wyman. Fluorescent human Rad51 reveals multiple nucleation sites and filament segments tightly associated along a single DNA molecule. Structure 2007 15:599-609
  • Moreno-Herrero,F., M. de Jager, N.H. Dekker, R. Kanaar, C. Wyman*and C. Dekker*. Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon DNA binding. Nature 2005 473:440-443. *corresponding author
  • Ristic, D., et al., Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function. Nucleic Acids Res 2005 33:3292-3302
  • Ristic, D., et al., The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. Proc. Natl. Acad. Sci. U S A 2001 98:8454-8460